Main and co-main event
Surging #3 contender Curtis Blaydes takes on recent title challenger and #4 ranked Francis Ngannou in a heavyweight main event rematch two and a half years in the making.
In the same division, #6 Alistair Overeem welcomes newcomer Sergey Pavlovich to the UFC in the co-main event.
Ngannou handed Blaydes his first, and so far only, professional loss of his career in Zagreb in April 2016.
That was via a doctor's stoppage in between rounds two and three, with Blaydes' right eye swollen shut.
In the last 12 months, Blaydes has picked up three top 10 wins over Aleksei Oleinik, Mark Hunt and Overeem.
Ngannou, meanwhile, has experienced huge highs and low lows inside the Octagon in the same period.
He knocked out Overeem last December with one of the most vicious finishes of the year, before taking on Stipe Miocic for the title just two months later.
It was somewhat of a humbling experience for the Cameroonian, who faded badly after a promising first round and lost a one-sided decision.
He returned in the co-main event at UFC 226 against Derrick Lewis in what many thought would be an exciting yet quick fight.
Instead, Ngannou looked like a shadow of the fighter who made such a devastating surge to title contention, barely throwing a strike a minute as Lewis took the decision.
The rematch with Blaydes is fascinating because Ngannou has looked so different in his last seven rounds of action to his previous encounters.
Blaydes, on the other hand, has mostly looked impressive in racking up some important wins.
If the Ngannou that showed up against Lewis shows up against Blaydes, it could get ugly.
The Reem faces a 12-0 Russian newcomer, who is a ferocious striker with a Greco-Roman wrestling background.
The Dutchman is coming off brutal losses to this event's headliners and will need to be back to his best to keep the 26-year-old debutant at bay.
Ones to watch
When looking at this card, three names immediately get my attention.
Firstly, Kevin Holland returns to action after his entertaining debut against Thiago Santos at UFC 227.
Holland came through Dana White's Tuesday Night Contender Series, although he did not get awarded a contract on the show.
According to White, he looked around for middleweights to take on Santos on short notice but could not find one to take the fight on less than two weeks' notice.
Despite the promise Holland showed on the DWTNCS, White himself was disappointed with the 26-year-olds style and brash talking during the fight.
He was, however, not only impressed with Holland for taking the fight with Santos, but also his actual performance in which he took the dangerous Brazilian knockout artist to a decision.
Holland returns against Welshman John Phillips, who was finished in his UFC debut back in May.
Secondly, another fighter returning for the first time since UFC 227 is Chinese strawweight Weili Zhang.
She has an extraordinary record for a strawweight and an even more impressive finishing rate.
The 29-year-old is 17-1 with a finishing rate of 88%, with nine (T)KOs and six submissions.
'Magnum' is also on a 17-fight winning streak, with her sole career loss to date coming in her debut in 2013 via unanimous decision.
She made her UFC debut against Danielle Taylor and won a unanimous decision, and takes on long-time strawweight Jessica Aguilar.
Aguilar herself had enjoyed a 10-fight winning streak heading into her UFC debut at UFC 190 in 2015, before losing out to Claudia Gadelha.
She has fought just twice since, losing out on a decision to Cortney Casey before returning to winning ways back in July against Jodie Esquibel.
Finally, 20-year-old Song Yadong returns against newcomer Vince Morales in a bantamweight clash.
Already 12-3 at the age of 20, Song has shown some genuine promise in his two UFC outings thus far.
He has picked up two performance bonuses thanks to a first round submission against Bharat Kandare in his debut and a round 2 finish over Felipe Arantes back in June in Singapore.
He has so far shown to be well-rounded and packing good power for the bantamweight division and it will be exciting to see him in main card action in his home country.